Not An Allergen.

This is a little tricky but let’s break it down: the most common alcohol (isopropyl, ethyl) used for disinfection is an irritant — and it is certainly drying —but it is not a common contact allergen. For more on the difference between irritant and allergic reactions, see It’s Complicated: Allergic Versus Irritant Reaction.

Complicating things somewhat: not all alcohols in skincare are liquids that dry out the skin. “Alcohol” is a categorization of a substance based on its atoms. There are many alcohols that aren’t drying, and many aren’t even liquid. Some alcohols that we don’t think of as alcohols are sperm oil, jojoba, rapeseed, mustard, and tallow. Some alcohols are beneficial (moisturizing!) to skin, like those from coconut and palm oils. Most alcohols are waxes (and waxes aren’t drying) from plants and beeswax. Lanolin, a fatty substance from sheep’s wool, is an allergen — far from being drying, lanolin is a common base in ointments. Allergen alcohols include benzyl alcohol and cinnamic alcohol.

For isopropyl and ethyl alcohol, its percentage in a product makes a difference. The higher the concentration, the more drying on the skin. Most astringents that are drying contain 85-90% alcohol (VMV Hypoallergenics Toners and Id Monolaurin Gel contain between 25% and 56%). In many countries, hand sanitizers must contain at least 70% alcohol. Because the antimicrobial action of our Kid Gloves Hand Sanitizer is primarily provided by monolaurin — which, along with virgin coconut oil, studies since the 1970s have shown to be as effective an antiviral and antimicrobial as 85% alcohol — we can limit its alcohol content to 38% (which is why it’s less drying than most hand sanitizers).

One more thing to consider: many alcohols used for disinfecting add moisturizers (to try to reduce the drying action on skin) and/or fragrances (to try to mask the inherent odor of alcohol). Some of these ingredients may be allergens and could actually cause more dryness or other skin reactions.

If you have a history of sensitive skin, don’t guess: random trial and error can cause more damage. Ask your dermatologist about a patch test.

To shop our selection of hypoallergenic products, visit vmvhypoallergenics.com. Need help? Ask us in the comments section below, or for more privacy (such as when asking us to customize recommendations for you based on your patch test results) contact us by email, or drop us a private message on Facebook.

For more:

On the prevalence of skin allergies, see Skin Allergies Are More Common Than Ever and One In Four Is Allergic to Common Skin Care And Cosmetic Ingredients.

To learn more about the VH-Rating System and hypoallergenicity, click here.

Main References: 

Regularly published reports on the most common allergens by the North American Contact Dermatitis Group and European Surveillance System on Contact Allergies (based on over 28,000 patch test results, combined), plus other studies. Remember, we are all individuals — just because an ingredient is not on the most common allergen lists does not mean you cannot be sensitive to it, or that it will not become an allergen. These references, being based on so many patch test results, are a good basis but it is always best to get a patch test yourself.

1. Warshaw, E.M., Maibach, H.I., Taylor, J.S., et al. North American contact dermatitis group patch test results: 2011-2012. Dermatitis. 2015; 26: 49-59

2. W Uter et al. The European Baseline Series in 10 European Countries, 2005/2006–Results of the European Surveillance System on Contact Allergies (ESSCA). Contact Dermatitis 61 (1), 31-38.7 2009

3. Wetter, DA et al. Results of patch testing to personal care product allergens in a standard series and a supplemental cosmetic series: An analysis of 945 patients from the Mayo Clinic Contact Dermatitis Group, 2000-2007. J Am Acad Dermatol. 2010 Nov;63(5):789-98.

4. Verallo-Rowell VM. The validated hypoallergenic cosmetics rating system: its 30-year evolution and effect on the prevalence of cosmetic reactions. Dermatitis 2011 Apr; 22(2):80-97

5. Ruby Pawankar et al. World Health Organization. White Book on Allergy 2011-2012 Executive Summary.

6. Misery L et al. Sensitive skin in the American population: prevalence, clinical data, and role of the dermatologist. Int J Dermatol. 2011 Aug;50(8):961-7.

7. Warshaw EM1, Maibach HI, Taylor JS, Sasseville D, DeKoven JG, Zirwas MJ, Fransway AF, Mathias CG, Zug KA, DeLeo VA, Fowler JF Jr, Marks JG, Pratt MD, Storrs FJ, Belsito DV. North American contact dermatitis group patch test results: 2011-2012.Dermatitis. 2015 Jan-Feb;26(1):49-59.

8. Warshaw, E et al. Allergic patch test reactions associated with cosmetics: Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2004. J AmAcadDermatol 2009;60:23-38. 

9. Foliaki S et al. Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase III. J Allergy Clin Immunol. 2009 Nov;124(5):982-9.

10. Kei EF et al. Role of the gut microbiota in defining human health. Expert Rev Anti Infect Ther. 2010 Apr; 8(4): 435–454.

11. Thavagnanam S et al. A meta-analysis of the association between Caesarean section and childhood asthma. Clin Exp Allergy. 2008;38(4):629–633.

12. Marks JG, Belsito DV, DeLeo VA, et al. North American Contact Dermatitis Group patch-test results, 1998 to 2000. Am J Contact Dermat. 2003;14(2):59-62.

13. Warshaw EM, Belsito DV, Taylor JS, et al. North American Contact Dermatitis Group patch test results: 2009 to 2010. Dermatitis. 2013;24(2):50-99.

14. Wetter DA, Yiannias JA, Prakash AV, Davis MD, Farmer SA, el-Azhary RA, et al. Results of patch testing to personal care product allergens in a standard series and a supplemental cosmetic series: an analysis of 945 patients from the Mayo Clinic Contact Dermatitis Group, 2000-2007. J Am Acad Dermatologist 2010;63:789-798

15. Swinnen I, Goossens A. Allergic contact dermatitis caused by ascorbic tetraisopalmitate. Contact Dermatitis 2011;64:241-242

16. Belhadjali H, Giordano-Labadie F, Bazex J. Contact dermatitis from vitamin C in a cosmetic anti-aging cream. Contact Dermatitis 2001;45:317

17. de Groot, A. Monographs in Contact Allergy: Non-Fragrance Allergens in Cosmetics (Parts 1 and 2). Boca Raton, FL: CRC Press; 2018. 

Want more great information on contact dermatitis? Check out the American Contact Dermatitis SocietyDermnet New Zealand, and your country’s contact dermatitis association.


Laura is our “dew”-good CEO at VMV Hypoallergenics and eldest daughter of VMV’s founding dermatologist-dermatopathologist. She has two children, Madison and Gavin, and works at VMV with her sister CC and husband Juan Pablo (Madison and Gavin frequently volunteer their “usage testing” services). In addition to saving the world’s skin, Laura is passionate about health, inclusion, cultural theory, human rights, happiness, and spreading goodness (like a great cream!)

The safest, most effective care on the planet